Dietary Polyphenols and Periodontitis—A Mini-Review of Literature

Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in clinical studies. These polyphenols also exhibit anti-inflammatory and antioxidant effects, which have the potential to impact various biological mechanisms for reducing the initiation and progression of periodontitis. The main objective of this mini-review is to focus on the mechanisms of action of dietary polyphenols in improving the pathophysiology underlying chronic inflammatory diseases like periodontitis based on pre-clinical and clinical models

Study of Uncertainties of Predicting Space Shuttle Thermal Environment

Quantitative estimates of the uncertainty in predicting aerodynamic heating rates for a fully reusable space shuttle system are developed and the impact of these uncertainties on Thermal Protection System (TPS) weight are discussed. The study approach consisted of statistical evaluations of the scatter of heating data on shuttle configurations about state-of-the-art heating prediction methods to define the uncertainty in these heating predictions. The uncertainties were then applied as heating rate increments to the nominal predicted heating rate to define the uncertainty in TPS weight. Separate evaluations were made for the booster and orbiter, for trajectories which included boost through reentry and touchdown. For purposes of analysis, the vehicle configuration is divided into areas in which a given prediction method is expected to apply, and separate uncertainty factors and corresponding uncertainty in TPS weight derived for each area

Analytical comparison of hypersonic flight and wind tunnel viscous/inviscid flow fields

Flow fields were computed about blunted, 0.524 and 0.698 radians, cone configurations to assess the effects of nonequilibrium chemistry on the flow field geometry, boundary layer edge conditions, boundary layer profiles, and heat transfer and skin friction. Analyses were conducted at typical space shuttle entry conditions for both laminar and turbulent boundary layer flow. In these calculations, a wall temperature of 1365 K (2000 F) was assumed. The viscous computer program used in this investigation was a modification of the Blottner non-similar viscous code which incorporated a turbulent eddy viscosity model after Cebeci. The results were compared with equivalent calculations for similar (scaled) configurations at typical wind tunnel conditions. Wind tunnel test gases included air, nitrogen, CF4 and helium. The viscous computer program used for wind tunnel conditions was the Cebeci turbulent non-similar computer code

Advanced electrostatic ion thruster for space propulsion

The suitability of the baseline 30 cm thruster for future space missions was examined. Preliminary design concepts for several advanced thrusters were developed to assess the potential practical difficulties of a new design. Useful methodologies were produced for assessing both planetary and earth orbit missions. Payload performance as a function of propulsion system technology level and cost sensitivity to propulsion system technology level are among the topics assessed. A 50 cm diameter thruster designed to operate with a beam voltage of about 2400 V is suggested to satisfy most of the requirements of future space missions

Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors

The development of emphysema is thought to be due to an imbalance of proteases (especially neutrophil elastase [NE]) and antiproteases with loosening of the respiratory epithelium as an early event. We investigated the effect of NE on respiratory epithelial cell adherence in vitro , in the presence of varying concentrations and combinations of native inhibitors, α-1-proteinase inhibitor (PI) and secretory leukoprotease inhibitor (SLPI). SLPI was two to 12 times more effective than PI at preventing the effects of NE, especially when enzyme:inhibitor ratios were almost equivalent. Even when the concentration of SLPI was only 10% of the total (as in normal peripheral lung secretions), it gave greater protection than PI alone. This suggests that SLPI plays an important role in controlling neutrophil elastaseinduced inflammation and tissue damage

Impact of Urban Growth on Surface Climate: A Case Study in Oran, Algeria

We develop a land use map discriminating urban surfaces from other cover types over a semiarid region in North Africa and use it in a land surface model to assess the impact of urbanized land on surface energy, water and carbon balances. Unlike in temperate climates where urbanization creates a marked heat island effect, this effect is not strongly marked in semiarid regions. During summer, the urban class results in an additional warming of 1.45 C during daytime and 0.81 C at night compared to that simulated for needleleaf trees under similar climate conditions. Seasonal temperatures show urban areas warmer than their surrounding during summer and slightly cooler in winter. The hydrological cycle is practically "shut down" during summer and characterized by relatively large amount of runoff in winter. We estimate the annual amount of carbon uptake to 1.94 million metric tons with only 11.9% assimilated during the rainy season. However, if urbanization expands to reach 50% of the total area excluding forests, the annual total carbon uptake will decline by 35% and the July mean temperature would increase only 0.10 C, compared to current situation. In contrast, if urbanization expands to 50% of the total land excluding forests and croplands but all short vegetation is replaced by native broadleaf deciduous trees, the annual carbon uptake would increase 39% and the July mean temperature would decrease by 0.9 C, compared to current configuration. These results provide guidelines for urban planners and land use managers and indicate possibilities for mitigating the urban heat

Landsat Data Continuity Mission - Launch Fever

The year 2013 will be an exciting period for those that study the Earth land surface from space, particularly those that observe and characterize land cover, land use, and the change of cover and use over time. Two new satellite observatories will be launched next year that will enhance capabilities for observing the global land surface. The United States plans to launch the Landsat Data Continuity Mission (LDCM) in January. That event will be followed later in the year by the European Space Agency (ESA) launch of the first Sentinel 2 satellite. Considered together, the two satellites will increase the frequency of opportunities for viewing the land surface at a scale where human impact and influence can be differentiated from natural change. Data from the two satellites will provide images for similar spectral bands and for comparable spatial resolutions with rigorous attention to calibration that will facilitate cross comparisons. This presentation will provide an overview of the LDCM satellite system and report its readiness for the January launch